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Forever Chemicals Linked to Metabolic Disease

colorful test tubes

Douglas Cliff from Getty Images/CanvaPro

A study led by researchers from Pennsylvania State University and published in Environmental Health Perspectives evaluated the effects of early life exposure to forever chemicals. The researchers focused on the effects of tetrachlorodibenzofuran (TCFD), a persistent organic pollutant, on a group of 4-week-old mice that were fed TCFD for five days, compared to the control group that did not ingest the chemical. They examined the animals’ gut microbiomes and other markers of metabolic disease after the initial five days and again three months later. The scientists found that the TCFD permanently disrupted the gut microbiome and caused a higher body weight and glucose intolerances after three months. These results suggest that human exposure to chemicals such as TCFD during childhood could contribute to metabolic disorders like obesity and Type 2 diabetes later in life.

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