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Novel Defense Against Infections

peptides

Kittisak Kaewchalun from Getty Images/CanvaPro

A study by Israeli researchers published in the journal Nature reported that cellular structures known as proteasomes not only facilitate the breakdown of damaged proteins, but also generate small protein fragments, collectively referred to as peptides, that attack bacterial infections. Using lab experiments and computer modeling, the scientists identified hundreds of thousands of potential antimicrobial peptides from normal proteasome activity.

The study demonstrated the enhanced ability of proteasomes to produce protective peptides when confronted with a bacterial infection. To test this, scientists inhibited proteasome production in one group of human cells and left another group unaltered. Both groups were then exposed to salmonella. The infection thrived within the cells lacking proteasomes but was eradicated in the control group. This discovery could lead to the development of improved antibiotics and other infection-fighting therapies

In-Print National Content Global and Health Briefs Health Brief July 2025
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Tick Talk

Spring officially sprung on March 21. We have turned our clocks ahead. We are looking forward to warm winds, sunny skies and the smell of fresh cut grass. The daffodils and tulips have recently bloomed and we are just starting with the yard work that comes with the warmer weather.  Sadly, another season has started ramping up.  Tick season.

•             The best form of protection is prevention. Educating oneself about tick activity and how our behaviors overlap with tick habitats is the first step.

•             According to the NJ DOH, in 2022 Hunterdon County led the state with a Lyme disease incidence rate of 426 cases per 100,000 people. The fact is ticks spend approximately 90% of their lives not on a host but aggressively searching for one, molting to their next stage or over-wintering. This is why a tick remediation program should be implemented on school grounds where NJ DOH deems high risk for tick exposure and subsequent attachment to human hosts.

•             Governor Murphy has signed a bill that mandates tick education in NJ public schools. See this for the details.  Tick education must now be incorporated into K-12 school curriculum. See link:

https://www.nj.gov/education/broadcasts/2023/sept/27/TicksandTick-BorneIllnessEducation.pdf

•             May is a great month to remind the public that tick activity is in full swing. In New Jersey, there are many tickborne diseases that affect residents, including Anaplasmosis, Babesiosis, Ehrlichiosis, Lyme disease, Powassan, and Spotted Fever Group Rickettsiosis.

•             For years, the focus has mainly been about protecting ourselves from Lyme disease. But other tick-borne diseases are on the rise in Central Jersey. An increase of incidence of Babesia and Anaplasma are sidelining people too. These two pathogens are scary because they effect our blood cells. Babesia affects the red blood cells and Anaplasma effects the white blood cells.

•             Ticks can be infected with more than one pathogen. When you contract Lyme it is possible to contract more than just that one disease. This is called a co-infection. It is super important to pay attention to your symptoms. See link.

https://twp.freehold.nj.us/480/Disease-Co-Infection

A good resource from the State:

https://www.nj.gov/health/cd/topics/tickborne.shtml

 

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