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Gene Technology Against Malaria

witsawat sananrum from Getty Images/CanvaPro

Each year, 263 million people contract malaria and 600,000 die from it worldwide. Malaria[1] spreads when an infected mosquito bites a person. Researchers have discovered a method to alter an amino acid in the mosquitoes, preventing the disease from reaching their salivary glands, the site of transmission. Their report in Nature[2]  details the use of CRISPR gene editing to modify the mosquito’s genome, changing the amino acid.

This genome change can then be disseminated through the mosquito population using a gene drive, which ensures that a specific mutation or gene is inherited by all offspring. Gene drive technology is controversial due to potential unforeseen negative impacts. A minor genomic change could lead to mutations in other parts of the genome, causing unintended changes that might disrupt the ecosystem’s balance.

The researchers hope to release these engineered mosquitoes into the wild and eventually eliminate the transmission of malaria. However, it will take several years before this technique is ready for field testing, which requires community and government approval.


 


 


In-Print National Content Global Brief Global and Health Briefs October 2025

 

 

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Tick Tackler

Spring officially sprung on March 21. We have turned our clocks ahead. We are looking forward to warm winds, sunny skies and the smell of fresh cut grass. The daffodils and tulips have recently bloomed and we are just starting with the yard work that comes with the warmer weather.  Sadly, another season has started ramping up.  Tick season.

•             The best form of protection is prevention. Educating oneself about tick activity and how our behaviors overlap with tick habitats is the first step.

•             According to the NJ DOH, in 2022 Hunterdon County led the state with a Lyme disease incidence rate of 426 cases per 100,000 people. The fact is ticks spend approximately 90% of their lives not on a host but aggressively searching for one, molting to their next stage or over-wintering. This is why a tick remediation program should be implemented on school grounds where NJ DOH deems high risk for tick exposure and subsequent attachment to human hosts.

•             Governor Murphy has signed a bill that mandates tick education in NJ public schools. See this for the details.  Tick education must now be incorporated into K-12 school curriculum. See link:

https://www.nj.gov/education/broadcasts/2023/sept/27/TicksandTick-BorneIllnessEducation.pdf

•             May is a great month to remind the public that tick activity is in full swing. In New Jersey, there are many tickborne diseases that affect residents, including Anaplasmosis, Babesiosis, Ehrlichiosis, Lyme disease, Powassan, and Spotted Fever Group Rickettsiosis.

•             For years, the focus has mainly been about protecting ourselves from Lyme disease. But other tick-borne diseases are on the rise in Central Jersey. An increase of incidence of Babesia and Anaplasma are sidelining people too. These two pathogens are scary because they effect our blood cells. Babesia affects the red blood cells and Anaplasma effects the white blood cells.

•             Ticks can be infected with more than one pathogen. When you contract Lyme it is possible to contract more than just that one disease. This is called a co-infection. It is super important to pay attention to your symptoms. See link.

https://twp.freehold.nj.us/480/Disease-Co-Infection

A good resource from the State:

https://www.nj.gov/health/cd/topics/tickborne.shtml

 

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