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Understanding How Magic Mushrooms Affect the Brain

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Psilocybin, a naturally psychedelic compound found in fungi known as magic mushrooms, distorts space-time perception. A 2024 study published in Nature investigated the brain activity of seven healthy adults before, during and three weeks after taking a high dose of psilocybin and methylphenidate, a stimulant commonly used to treat attention-deficit/hyperactivity disorder. Participants returned six to 12 months later for another psilocybin dose. Researchers used 18 magnetic resonance images (MRI) to track specific brain changes.

The study revealed that psilocybin significantly disrupted brain connectivity pathways, particularly in regions of the brain linked to self-awareness, time and space, with the most notable changes in the default mode network (DMN). The DMN includes brain regions associated with the sense of self and reality that are active during self-reflection, daydreaming, memory retrieval and mind-wandering.

Psilocybin’s disruption of brain activity could explain the profound changes in perception reported by users. Participants with greater brain changes reported more intense experiences.  The brain connectivity desynchronization persisted for weeks, potentially explaining the enduring therapeutic benefits in treating conditions like depression.

In-Print National Content Global and Health Briefs Health Brief December 2025

 

 

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Tick Tackler

Spring officially sprung on March 21. We have turned our clocks ahead. We are looking forward to warm winds, sunny skies and the smell of fresh cut grass. The daffodils and tulips have recently bloomed and we are just starting with the yard work that comes with the warmer weather.  Sadly, another season has started ramping up.  Tick season.

•             The best form of protection is prevention. Educating oneself about tick activity and how our behaviors overlap with tick habitats is the first step.

•             According to the NJ DOH, in 2022 Hunterdon County led the state with a Lyme disease incidence rate of 426 cases per 100,000 people. The fact is ticks spend approximately 90% of their lives not on a host but aggressively searching for one, molting to their next stage or over-wintering. This is why a tick remediation program should be implemented on school grounds where NJ DOH deems high risk for tick exposure and subsequent attachment to human hosts.

•             Governor Murphy has signed a bill that mandates tick education in NJ public schools. See this for the details.  Tick education must now be incorporated into K-12 school curriculum. See link:

https://www.nj.gov/education/broadcasts/2023/sept/27/TicksandTick-BorneIllnessEducation.pdf

•             May is a great month to remind the public that tick activity is in full swing. In New Jersey, there are many tickborne diseases that affect residents, including Anaplasmosis, Babesiosis, Ehrlichiosis, Lyme disease, Powassan, and Spotted Fever Group Rickettsiosis.

•             For years, the focus has mainly been about protecting ourselves from Lyme disease. But other tick-borne diseases are on the rise in Central Jersey. An increase of incidence of Babesia and Anaplasma are sidelining people too. These two pathogens are scary because they effect our blood cells. Babesia affects the red blood cells and Anaplasma effects the white blood cells.

•             Ticks can be infected with more than one pathogen. When you contract Lyme it is possible to contract more than just that one disease. This is called a co-infection. It is super important to pay attention to your symptoms. See link.

https://twp.freehold.nj.us/480/Disease-Co-Infection

A good resource from the State:

https://www.nj.gov/health/cd/topics/tickborne.shtml

 

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