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Predicting Dementia

brain scans

serdar415 from Getty Images AndreyPopov from Getty Images/CanvaPro Signature/CanvaPro

Determining how fast a brain ages may help predict and prevent dementia, a condition that is projected to impact approximately 42 percent of Americans aged 55 and older, according to the National Institutes of Health. While genetic analysis at the cellular level offers insights into biological age, its application to brain cells is hindered by the blood-brain barrier, which prevents cell collection.

Researchers from the University of Southern California have devised a non-invasive method that integrates magnetic resonance imaging (MRI) with artificial intelligence (AI) to assess brain aging. Their findings were published in Proceedings of the National Academy of Sciences of the United States of America.

The AI database was constructed through an exhaustive analysis of thousands of brain scans from individuals with different brain conditions and varying ages. Subsequently, patient brain scans taken at distinct time intervals are compared to the database to identify brain zones that are exhibiting accelerated aging. The method was tested on more than 100 adults with healthy brains and 140 Alzheimer's patients. The researchers are optimistic that their approach will not only identify early signs of cognitive decline but also facilitate the prediction of disease progression.

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